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Understanding Ratios & Formulations

Medical cannabis products are produced in a number of formulations or ratios, representing a blend of two primary cannabinoids: CBD and THC. When describing a product formulation, the first number listed in the ratio is the parts CBD medicine, the second number is the parts THC medicine.

To satisfy the conditions approved in the state of Texas under the Compassionate Use Program, licensees in this state are only allowed to produce cannabis extracts containing 0.5% THC by weight. This makes it possible for licensees to produce only what are referred to as High-CBD and Balanced formulations.

High-CBD Formulation (20:1)

  • High-CBD formulations have much higher CBD content by weight – up to 20 times the amount of THC.
  • Clinical research suggests that High-CBD formulations can have a positive impact on symptoms associated with the following conditions:
    • Epilepsy and other seizure disorders
    • Autism

Balanced Formulations (3:1 & 1:1)

  • Balanced formulations have relatively similar levels of CBD and THC by weight
  • Clinical research suggests that Balanced formulations can have a positive impact on symptoms associated with the following conditions:
    • Autism
    • Multiple sclerosis
    • Spasticity
    • Terminal cancer
    • ALS
    • Other neurodegenerative diseases

Which Formulation Is Best For You?

Use the chart below to cross reference specific conditions with associated symptoms and the recommended formulation for treatment.

Symptoms Epilepsy Autism Multiple Sclerosis Spasticity Terminal Cancer ALS
Anxiety High-CBD High-CBD High-CBD
Depression High-CBD
Seizures High-CBD High-CBD
Restlessness High-CBD
Disruptive Behavior High-CBD
Pain Balanced Balanced Balanced Balanced
Appetite Loss Balanced Balanced
Muscle Spasm Balanced Balanced Balanced
Insomnia Balanced Balanced
Nausea Balanced
Tics Balanced

Dosing Information

Like most new medications, dosage recommendations for cannabis medicines are best established according to existing scientific research, careful integration of high-quality anecdotal evidence, and incorporation of individual patient outcomes. The dose-finding process will be different for each patient, the discovery process occurring alongside individualized titration guided by their physician. As more patients join the program and the knowledge base for physicians grows, prescribers will gain a better understanding of efficacy and how patients tolerate medical cannabis treatment.